Vitamin D receptor agonists and kidney diseases
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Vitamin D receptor agonists and kidney diseases by Theodoros Eleftheriadis

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Published by Nova Science Publishers in Hauppauge, N.Y .
Written in English

Book details:

Edition Notes

Includes bibliographical references and index.

StatementTheodoros Eleftheriadis, Vassilios Liakopoulos
ContributionsLiakopoulos, Vassilios
LC ClassificationsRC903.9 .E44 2010
The Physical Object
Paginationp. ;
ID Numbers
Open LibraryOL24538977M
ISBN 109781616688608
LC Control Number2010025381

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Vascular calcification is common in chronic kidney disease, where cardiovascular mortality remains the leading cause of death. Patients with kidney disease are often prescribed vitamin D receptor agonists (VDRAs) that confer a survival benefit, but the underlying mechanisms remain unclear. Here we tested two VDRAs in a mouse chronic kidney disease model where dietary phosphate loading induced Cited by: CKD, chronic kidney disease; ESRD, end-stage renal disease; HD, hem odialysis; PD, peritoneal dialysis; VDRA, vitamin D receptor activator. Kidney International () 73, – Hyperparathyroidism occurs in most patients during the progression of chronic kidney disease (CKD) and one of its initiating events, reduced serum levels of 1,dihydroxyvitamin D, results from a decrease in renal 1α hydroxylase activity, which converts hydroxyvitamin D to its activated form. The combination of persistently high parathyroid hormone (PTH) and low 1,dihydroxyvitamin D is Cited by:   Abstract. The biologically most active vitamin D metabolite, 1,dihydroxyvitamin D 3 [calcitriol or 1,25(OH) 2 D 3] exerts the vast majority of its classical actions and attributed “non-traditional” effects by means of interaction with the vitamin D receptor (VDR).Here, we review the VDR structure and function, as well as the molecular actions of vitamin D mediated via this classical.

As kidney disease develops, there is decreased functional renal mass and a reduction in renal 1α-hydroxylase activity and thus in renal production of calcitriol at very early CKD stages. Recently, a potentially important role of vitamin D receptor activation (VDRa) in the survival of patients undergoing dialysis has been suggested.   Vitamin D Receptor Agonists and BPH-Related Luts Hypertrophy and increased contractility of bladder musculature characterize the early stages of BPH-related bladder dysfunction, mainly representing a compensatory response to the urethral obstruction caused by .   The Role of Vitamin D and CKD-Mineral Bone Disorders. CKD is associated with a progressive impairment of vitamin D metabolism, declining circulating 1,25(OH) 2 D 3 levels and resultant alterations in S[Ca] and S[P], fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) levels. In addition 25(OH)D levels are reduced in many CKD patients.   Kidney Damage and Other Health Problems That Occur from Too Much Vitamin D Written by Elizabeth Pratt on Ap Share on Pinterest .

1. Kidney Int. Jun;73(12) doi: /ki Epub Feb Vitamin D receptor activation and survival in chronic kidney disease. Control of secondary hyperparathyroidism by vitamin D receptor agonists in chronic kidney disease Clin J Am Soc Nephrol. Mar;5(3) doi: /CJN Vitamin D deficiency (kidney disease (CKD) or undergoing dialysis. Mounting evidence from animal and clinical studies has suggested that Vitamin D Receptor (VDR) activation has beneficial effects on various renal diseases.